St. Nicholas Greek Orthodox Church was the only place of worship destroyed during the September 11, 2001 attacks. The Church was originally built in 1916 by Greek immigrants and stood across the World Trade Center in New York City. When the South Tower collapsed, the Church was flattened. No one was inside when the church was destroyed and very little of its content was ever recovered. 

In a special ceremony and service, held on October 18, Archbishop Demetrios, leader of the Greek Orthodox Church in America blessed the rebuilding of the church. The Spanish architect Santiago Calatrava, who is responsible for the designs said he drew inspiration from Hagia Sophia.

The new church will be delivered in 2016, to commemorate its 100th anniversary. Archbishop Demetrios said "it will be a place of faith, a place of peace, solace and hope."